Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysisReportar como inadecuado




Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Neural Transmission

, Volume 116, Issue 3, pp 275–289

First Online: 26 November 2008Received: 14 July 2008Accepted: 29 October 2008

Abstract

Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin-oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.

KeywordsSchizophrenia Proteomics Anterior temporal lobe ICPL Oligodendrocytes Myelin Calcium Biomarker C. W. Turck and E. Dias-Neto have contributed equally to this work.

Download fulltext PDF



Autor: Daniel Martins-de-Souza - Wagner F. Gattaz - Andrea Schmitt - Christiane Rewerts - Sérgio Marangoni - José C. Novello -

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados