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Oxidative Medicine and Cellular LongevityVolume 2012 2012, Article ID 282438, 12 pages

Review Article

Department of Physiology, Faculty of Medicine, The Complutense University, Plaza Ramón y Cajal s-n., 28040 Madrid, Spain

Danish Center for Aging Research, Danish Center for Molecular Gerontology, and Department of Molecular Biology and Genetics, Aarhus University, C.F. Møellers Allé 3, Building 1130, 8000 Aarhus C, Denmark

Received 1 July 2012; Accepted 26 August 2012

Academic Editor: Heinz D. Osiewacz

Copyright © 2012 Ricardo Gredilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Knowledge about the different mechanisms underlying the aging process has increased exponentially in the last decades. The fact that the basic mechanisms involved in the aging process are believed to be universal allows the use of different model systems, from the simplest eukaryotic cells such as fungi to the most complex organisms such as mice or human. As our knowledge on the aging mechanisms in those model systems increases, our understanding of human aging and the potential interventions that we could approach rise significantly. Among the different mechanisms that have been implicated in the aging process, DNA repair is one of the processes which have been suggested to play an important role. Here, we review the latest investigations supporting the role of these mechanisms in the aging process, stressing how beneficial the use of different model systems is. We discuss how human genetic studies as well as several investigations on mammalian models and simpler eukaryotic organisms have contributed to a better understanding of the involvement of DNA repair mechanisms in aging.

Autor: Ricardo Gredilla, Christian Garm, and Tinna Stevnsner



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