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The Journal of Headache and Pain

, Volume 11, Issue 3, pp 235–240

First Online: 29 January 2010Received: 16 October 2009Accepted: 12 January 2010


The purpose of this study was to analyse the comorbidity between headache and epilepsy in a large series of children with headache 1,795. Fifty-six cases 3.1% suffered from idiopathic headache and idiopathic or cryptogenic epilepsy or unprovoked seizures. There was a strong association between migraine and epilepsy: in migraineurs 46-56 the risk of epilepsy was 3.2 times higher when compared with tension-type headache, without significant difference between migraine with and without aura P = 0.89; children with epilepsy had a 4.5-fold increased risk of developing migraine than tension-type headache. In cases with comorbidity, focal epilepsies prevailed 43-56, 76.8%. Migraineurs affected by focal epilepsies 36-56 had a three times higher risk of having a cryptogenic epilepsy 27-36, 75% than an idiopathic epilepsy 9-36, 25% P = 0.003. In migraine with aura, epilepsy preceded migraine in 71% of cases. Photosensitivity 7-56, 12.5% and positive family history for epilepsy 22-56, 39% were frequent in cases with comorbidity.

KeywordsHeadache Migraine Epilepsy Comorbidity Children  Download fulltext PDF



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