A systematic review of population based epidemiological studies in Myasthenia GravisReportar como inadecuado




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BMC Neurology

, 10:46

First Online: 18 June 2010Received: 17 November 2009Accepted: 18 June 2010

Abstract

BackgroundThe aim was to collate all myasthenia gravis MG epidemiological studies including AChR MG and MuSK MG specific studies. To synthesize data on incidence rate IR, prevalence rate PR and mortality rate MR of the condition and investigate the influence of environmental and technical factors on any trends or variation observed.

MethodsStudies were identified using multiple sources and meta-analysis performed to calculate pooled estimates for IR, PR and MR.

Results55 studies performed between 1950 and 2007 were included, representing 1.7 billion population-years. For All MG estimated pooled IR eIR: 5.3 per million person-years C.I.:4.4, 6.1, range: 1.7 to 21.3; estimated pooled PR: 77.7 per million persons C.I.:64.0, 94.3, range 15 to 179; MR range 0.1 to 0.9 per millions person-years. AChR MG eIR: 7.3 C.I.:5.5, 7.8, range: 4.3 to 18.0; MuSK MG IR range: 0.1 to 0.32. However marked variation persisted between populations studied with similar methodology and in similar areas.

ConclusionsWe report marked variation in observed frequencies of MG. We show evidence of increasing frequency of MG with year of study and improved study quality. This probably reflects improved case ascertainment. But other factors must also influence disease onset resulting in the observed variation in IR across geographically and genetically similar populations.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-10-46 contains supplementary material, which is available to authorized users.

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Autor: Aisling S Carr - Chris R Cardwell - Peter O McCarron - John McConville

Fuente: https://link.springer.com/







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