Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patientsReport as inadecuate

Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients - Download this document for free, or read online. Document in PDF available to download.

Journal of Neurology

, Volume 258, Issue 4, pp 670–676

First Online: 02 March 2011Received: 21 October 2010Revised: 10 February 2011Accepted: 11 February 2011


Fatigue is a common but often overlooked symptom after stroke. This study investigated whether stroke type, infarct volume, and laterality, as well as the levels of various cytokines and other blood components in the acute phase of acute ischemic stroke AIS, can predict the level of fatigue at 6, 12, and 18 months after its onset. In 45 patients with acute stroke, serum levels of C-reactive protein, hemoglobin, glucose, and 13 cytokines were measured within 72 h of stroke onset. The cytokine measurements were performed using BioPlex XMap technology Luminex. The acute serum levels of interleukin IL-1β and glucose were positively correlated with the score on the Fatigue Severity Scale FSS at 6 months after the stroke r = 0.37, p = 0.015, and r = 0.37, p = 0.017, respectively. The acute serum levels of IL-ra and IL-9 were negatively correlated with FSS score at 12 months after the stroke r = −0.38, p = 0.013, and r = −0.36, p = 0.019, respectively. The FSS score at 12 months after stroke was significantly lower in patients with radiologically confirmed infarction than in those without such confirmation p = 0.048. The FSS score at 18 months was not correlated with any of the measured variables. High acute serum levels of glucose and IL-1β, and low IL1-ra and IL-9 may predict fatigue after AIS, indicating that the development of poststroke fatigue can be accounted for by the proinflammatory response associated with AIS. These novel findings support a new cytokine theory of fatigue after stroke. However, more research is needed to validate the results of this study.

KeywordsAcute ischemic stroke Inflammation Cytokines Proinflammatory Anti-inflammatory An erratum to this article can be found at

Download fulltext PDF

Author: Heidi Ormstad - Hans Christian Dalsbotten Aass - Karl-Friedrich Amthor - Niels Lund-Sørensen - Leiv Sandvik


Related documents