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European Archives of Psychiatry and Clinical Neuroscience

, Volume 261, Issue 3, pp 179–184

First Online: 10 November 2010Received: 09 July 2010Accepted: 25 October 2010

Abstract

Verbal and visuospatial working memory WM impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression MDD the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies. Eighteen MDD patients and 18 healthy controls matched with regard to age, gender and education were tested using process- and circuit-specific WM tasks for which clear brain-behaviour relationships had been established in prior functional neuroimaging studies. Patients suffering from acute MDD showed a selective impairment in articulatory rehearsal of verbal information in working memory. By contrast, visuospatial WM was unimpaired in this sample. There were no significant correlations between symptom severity and WM performance. These data indicate a dysfunction of a specific verbal WM system in acutely ill patients with MDD. As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients.

KeywordsMajor depression Neurocognition Cognitive endophenotype Psychosis Brain imaging O. Gruber, D. Zilles and J. Kennel have contributed equally.

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Autor: Oliver Gruber - David Zilles - Jennifer Kennel - Eva Gruber - Peter Falkai

Fuente: https://link.springer.com/







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