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BioMed Research International - Volume 2016 2016, Article ID 2056786, 17 pages -

Review Article

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, 76230 Santiago de Querétaro, QRO, Mexico

Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN-Sede Sur, 14330 Mexico City, Mexico

Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Mexico City, Mexico

Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, 88740 Reynosa, TAMPS, Mexico

Received 31 May 2016; Revised 12 November 2016; Accepted 27 November 2016

Academic Editor: John D. Wade

Copyright © 2016 Abimael González-Hernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Calcitonin gene-related peptide CGRP is a 37-amino-acid neuropeptide belonging to the calcitonin gene peptide superfamily. CGRP is a potent vasodilator with potential therapeutic usefulness for treating vascular-related disease. This peptide is primarily located on C- and Aδ-fibers, which have extensive perivascular presence and a dual sensory-efferent function. Although CGRP has two major isoforms α-CGRP and β-CGRP, the α-CGRP is the isoform related to vascular actions. Release of CGRP from afferent perivascular nerve terminals has been shown to result in vasodilatation, an effect mediated by at least one receptor the CGRP receptor. This receptor is an atypical G-protein coupled receptor GPCR composed of three functional proteins: i the calcitonin receptor-like receptor CRLR; a seven-transmembrane protein, ii the activity-modifying protein type 1 RAMP1, and iii a receptor component protein RCP. Although under physiological conditions, CGRP seems not to play an important role in vascular tone regulation, this peptide has been strongly related as a key player in migraine and other vascular-related disorders e.g., hypertension and preeclampsia. The present review aims at providing an overview on the role of sensory fibers and CGRP release on the modulation of vascular tone.





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