Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid SynthesisReportar como inadecuado




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Journal of ObesityVolume 2012 2012, Article ID 205648, 12 pages

Research Article

Division of Digestive and Liver Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

Division of Preventive Medicine and Nutrition, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

Received 13 May 2011; Revised 8 August 2011; Accepted 8 August 2011

Academic Editor: Ivana Zavaroni

Copyright © 2012 Fengxia Ge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A nonarteriosclerotic cardiomyopathy is increasingly seen in obese patients. Seeking a rodent model, we studied cardiac histology, function, cardiomyocyte fatty acid uptake, and transporter gene expression in male C57BL-6J control mice and three obesity groups: similar mice fed a high-fat diet HFD and db-db and ob-ob mice. At sacrifice, all obesity groups had increased body and heart weights and fatty livers. By echocardiography, ejection fraction EF and fractional shortening FS of left ventricular diameter during systole were significantly reduced. The 𝑉max for saturable fatty acid uptake was increased and significantly correlated with cardiac triglycerides and insulin concentrations. 𝑉max also correlated with expression of genes for the cardiac fatty acid transporters Cd36 and Slc27a1. Genes for de novo fatty acid synthesis Fasn, Scd1 were also upregulated. Ten oxidative phosphorylation pathway genes were downregulated, suggesting that a decrease in cardiomyocyte ATP synthesis might explain the decreased contractile function in obese hearts.





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Fuente: https://www.hindawi.com/



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