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Journal of Neurology

, Volume 259, Issue 2, pp 311–317

First Online: 03 August 2011Received: 29 June 2011Accepted: 12 July 2011


Relapse rate is decreased during pregnancy in multiple sclerosis MS. Risk for postpartum relapse is increased in the first 3 months after delivery. We aimed to study clinical course of MS around pregnancy, using clinical as well as self-report scales, including data on quality of life QoL, and to identify clinical factors predisposing for postpartum relapse. We performed a prospective, longitudinal study among 35 MS patients and 20 controls. In patients we assessed expanded disability status scale EDSS, the Guy’s neurological disability scale GNDS and the multiple sclerosis impact scale 29 MSIS-29. In patients and controls we assessed the MOS 36 item short form health survey questionnaire SF36, consisting of eight domains. The previously described surge in relapses after delivery was also obvious in this study p = 0.005. At group level EDSS and MSIS-29 did not show overt fluctuations over time. The GNDS, however, improved during the third trimester, compared to the first trimester p = 0.003. A concomitant improvement in the SF36 domains vitality p < 0.001 and general health p = 0.001 was found in patients. At the final visit, at least 9 months after delivery, no worsening of EDSS, GNDS, MSIS-29 or SF36 was observed compared with the for MS, beneficial third trimester. Duration of disease, relapses in the year preceding pregnancy or relapses during pregnancy were not associated with postpartum relapse. QoL is improved during pregnancy. Although relapse rate was increased directly after delivery, in the mid long term after delivery no adverse effects of pregnancy on MS were found.

KeywordsMultiple sclerosis Pregnancy Quality of life Postpartum relapse  Download fulltext PDF

Autor: R. F. Neuteboom - A. C. J. W. Janssens - T. A. M. Siepman - I. A. Hoppenbrouwers - I. A. Ketelslegers - N. Jafari -


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