Electroacupuncture at 2-100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder RatsReport as inadecuate




Electroacupuncture at 2-100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder Rats - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 205316, 14 pages

Research ArticleDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenue Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil

Received 20 June 2013; Accepted 14 August 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Josie Resende Torres da Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the effects of intrathecal injection of desipramine and fluoxetine selective inhibitors of norepinephrine and 5-HT uptake, resp., thiorphan and neostigmine inhibitors of enkephalinase and acetylcholinesterase, resp., gabapentin a GABA releaser, and vigabatrin an inhibitor of GABA-transaminase on the antinociception induced by 2 Hz, 100 Hz, or 2-100 Hz electroacupuncture EA applied bilaterally to the Zusanli ST36 and Sanyinjiao SP6 acupoints using the rat tail-flick test. We show that 2 Hz EA antinociception lasts longer after the administration of drugs that increase the spinal availability of norepinephrine, acetylcholine, or GABA; 100 Hz EA antinociception lasts longer after drug that increases the spinal availability of norepinephrine; 2-100 Hz EA antinociception lasts longer after drugs that increase the spinal availability of endogenous opioids or GABA. We conclude that the antinociceptive effect of 2-100 Hz EA is different from the synergistic effect of alternate stimulation at 2 and 100 Hz because the effect of the former is not changed by increasing the spinal availability of serotonin and lasts longer after the administration of vigabatrin. The combination of EA with drugs that increase the availability of spinal neurotransmitters involved in the modulation of nociceptive inputs may result in a synergistic antinociceptive effect in the rat tail-flick test.





Author: Josie Resende Torres da Silva, Marcelo Lourenço da Silva, and Wiliam Alves Prado

Source: https://www.hindawi.com/



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