Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of trypanosoma cruzi Report as inadecuate




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Marialba Avezum Alves Castro-Prado ; Max Jean de Ornelas Toledo ; Silvana Marques Araújo ; Mônica Lúcia Gomes ;Acta Scientiarum. Health Sciences 2012, 34

Author: Edilson Nobuyoshi Kaneshima

Source: http://www.redalyc.org/articulo.oa?id=307226825014


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Acta Scientiarum.
Health Sciences ISSN: 1679-9291 eduem@uem.br Universidade Estadual de Maringá Brasil Nobuyoshi Kaneshima, Edilson; Alves Castro-Prado, Marialba Avezum; de Ornelas Toledo, Max Jean; Marques Araújo, Silvana; Gomes, Mônica Lúcia Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi Acta Scientiarum.
Health Sciences, vol.
34, 2012, pp.
321-327 Universidade Estadual de Maringá Maringá, Brasil Available in: http:--www.redalyc.org-articulo.oa?id=307226825014 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Acta Scientiarum http:--www.uem.br-acta ISSN printed: 1679-9291 ISSN on-line: 1807-8648 Doi: 10.4025-actascihealthsci.v34ispec.12337 Trypanocidal activity of genotoxic concentration of benznidazole on epimastigote forms of Trypanosoma cruzi Edilson Nobuyoshi Kaneshima*, Marialba Avezum Alves Castro-Prado, Max Jean de Ornelas Toledo, Silvana Marques Araújo and Mônica Lúcia Gomes Universidade Estadual de Maringá, Av.
Colombo, 5790, 87020-900, Maringá, Paraná, Brazil.
*Author for correspondence.
E-mail: enkaneshima@uem.br ABSTRACT.
The genotoxicity of benznidazole at a concentration of 75 μM, used in the treatment of Chagas’ disease, has been recently reported.
The present study evaluated the inhibitory effect of benznidazole on the growth of epimastigote forms of T.
cruzi I and II by using genotoxic (75 μM) and nongenotoxic (50 μM) concentrations.
To assess the growth rates of T.
cruzi strains G2, A2.1A, CL, Y, and 2052, parasites in the epimastigote form were cultured in LIT medium for 192 h at 28ºC, with (50 and 75 μM) and without (negative control) benznidazole.
Benznidazole at both concentrations inhibited all the strains, regardless of gene...





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