Cerebral blood flow characteristics in patients with post-lumbar puncture headacheReport as inadecuate

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Journal of Neurology

, Volume 259, Issue 4, pp 665–669

First Online: 21 September 2011Received: 02 June 2011Revised: 12 August 2011Accepted: 30 August 2011


The aim of this study was to verify if diagnostic lumbar puncture DLP in post-lumbar puncture headache PLPH patients is related to significant changes in cerebral blood flow which could be visualized by transcranial Doppler TCD. Sixty-six patients were enrolled in this study. TCD was performed 24 h before DLP and repeated within 24 h after the procedure. The measurements included mean velocity Vmean, peak systolic velocity Vmax, and Gosling’s pulsatility index PI, in the left and right middle cerebral artery MCA. PLPH was observed in 21 patients 32%. No significant differences were noted in Vmean, Vmax and PI between the right and left MCAs—both before DLP and following this procedure. In patients who developed PLPH, bilateral pre-puncture values of Vmean and Vmax were significantly higher and PI was significantly lower compared to unaffected individuals. No significant differences were observed between these groups in terms of post-puncture Vmean and Vmax, but the post-puncture PI was still significantly lower in PLPH cases. In PLPH cases, the post-puncture values of Vmean and Vmax were significantly lower than the respective baseline parameters. A significant inverse correlation was present between PLPH severity and bilateral pre-puncture PI. In conclusion, this study revealed that higher baseline values of Vmean and Vmax and low PI in bilateral MCAs predispose patients to PLPH.

KeywordsCerebral hemodynamics Flow velocity Intracranial pressure Post-lumbar puncture headache Transcranial Doppler  Download fulltext PDF

Author: Magdalena Nowaczewska - Barbara Książkiewicz

Source: https://link.springer.com/

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