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Journal of Nanomaterials - Volume 2015 2015, Article ID 204961, 10 pages -

Research ArticleDepartment of Chemistry, Villanova University, Villanova, PA 19085, USA

Received 14 November 2014; Accepted 28 January 2015

Academic Editor: Nurit Beyth

Copyright © 2015 Madeline Rotella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Surface functionalization of nanomaterials is an area of current investigation that supports the development of new biomaterials for applications in biology and medicine. Herein we describe the synthesis, characterization, and antibacterial properties of the first examples of antibiotic-labeled graphitic carbon nanofibers GCNFs covalently functionalized with aminoglycoside and quinolone antibiotics. Ruthenium tetroxide oxidation of herringbone GCNFs gave higher amounts of surface carboxyl groups than previous methods. These carboxyl groups served as sites of attachment for antibiotics by acyl substitution. Bioassay of these novel, functionalized GCNFs using serial dilution and optical density methods demonstrated that antibiotic-labeled GCNFs possess significant antibacterial activity against Pseudomonas aeruginosa. The activity we observe for aminoglycoside-functionalized GCNFs suggests a membranolytic mechanism of action.

Autor: Madeline Rotella, Alicia Briegel, John Hull, Anthony Lagalante, and Robert Giuliano



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