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Medical Gas Research

, 2:11

First Online: 19 April 2012Received: 03 January 2012Accepted: 19 April 2012


This article summarized findings of current preclinical studies that implemented hydrogen administration, either in the gas or liquid form, as treatment application for neurological disorders including traumatic brain injury TBI, surgically induced brain injury SBI, stroke, and neonatal hypoxic-ischemic brain insult HI. Most reviewed studies demonstrated neuroprotective effects of hydrogen administration. Even though anti-oxidative potentials have been reported in several studies, further neuroprotective mechanisms of hydrogen therapy remain to be elucidated. Hydrogen may serve as an adjunct treatment for neurological disorders.

KeywordsHydrogen Neuroprotection Oxidative stress Reactive oxygen species AbbreviationsBBBBlood brain barrier


H2SHydrogen sulfide

HINeonatal hypoxia-ischemia

ICHIntracerebral hemorrhage

ROSReactive oxygen species

MCAMiddle cerebral artery

SAHSubarachnoid hemorrhage

TBITraumatic brain injury

tMCAOTransient middle cerebral artery occlusion

TTC2:3:5-triphenyltetrazolium chloride.

Electronic supplementary materialThe online version of this article doi:10.1186-2045-9912-2-11 contains supplementary material, which is available to authorized users.

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Autor: Jan M Eckermann - Paul R Krafft - Lorelei Shoemaker - Robert E Lieberson - Steven D Chang - Austin Colohan

Fuente: https://link.springer.com/

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