A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes - Physics > Biological PhysicsReportar como inadecuado




A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes - Physics > Biological Physics - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Abstract: Microtubules are a major component of the cytoskeleton distinguished byhighly dynamic behavior both in vitro and in vivo. We propose a generalmathematical model that accounts for the growth, catastrophe, rescue andnucleation processes in the polymerization of microtubules from tubulin dimers.Our model is an extension of various mathematical models developed earlierformulated in order to capture and unify the various aspects of tubulinpolymerization including the dynamic instability, growth of microtubules tosaturation, time-localized periods of nucleation and depolymerization as wellas synchronized oscillations exhibited by microtubules under variousexperimental conditions. Our model, while attempting to use a minimal number ofadjustable parameters, covers a broad range of behaviors and has predictivefeatures discussed in the paper. We have analyzed the resultant behaviors ofthe microtubules changing each of the parameter values at a time and observingthe emergence of various dynamical regimes.



Autor: Peter Hinow, Vahid Rezania, Jack A. Tuszynski

Fuente: https://arxiv.org/







Documentos relacionados