Early microstructural white matter changes in patients with HIV: A diffusion tensor imaging studyReport as inadecuate

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BMC Neurology

, 12:23

Cerebrovascular disease and stroke


BackgroundPrevious studies have reported white matter WM brain alterations in asymptomatic patients with human immunodeficiency virus HIV.

MethodsWe compared diffusion tensor imaging DTI derived WM fractional anisotropy FA between HIV-patients with and without mild macroscopic brain lesions determined using standard magnetic resonance imaging MRI. We furthermore investigated whether WM alterations co-occurred with neurocognitive deficits and depression. We performed structural MRI and DTI for 19 patients and 19 age-matched healthy controls. Regionally-specific WM integrity was investigated using voxel-based statistics of whole-brain FA maps and region-of-interest analysis. Each patient underwent laboratory and neuropsychological tests.

ResultsStructural MRI revealed no lesions in twelve HIV-MRN and unspecific mild macrostructural lesions in seven patients HIV-MRL. Both analyses revealed widespread FA-alterations in all patients. Patients with HIV-MRL had FA-alterations primarily adjacent to the observed lesions and, whilst reduced in extent, patients with HIV-MRN also exhibited FA-alterations in similar regions. Patients with evidence of depression showed FA-increase in the ventral tegmental area, pallidum and nucleus accumbens in both hemispheres, and patients with evidence of HIV-associated neurocognitive disorder showed widespread FA-reduction.

ConclusionThese results show that patients with HIV-MRN have evidence of FA-alterations in similar regions that are lesioned in HIV-MRL patients, suggesting common neuropathological processes. Furthermore, they suggest a biological rather than a reactive origin of depression in HIV-patients.

KeywordsDepression HIV-associated neurocognitive disorder Fractional anisotropy Neuropsychology Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-12-23 contains supplementary material, which is available to authorized users.

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Author: Bianca Stubbe-Drger - Michael Deppe - Siawoosh Mohammadi - Simon S Keller - Harald Kugel - Nora Gregor - Stefan Evers - Pe

Source: https://link.springer.com/

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