Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studiesReportar como inadecuado




Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Neurological Sciences

, Volume 33, Supplement 1, pp 65–69

First Online: 30 May 2012

Abstract

The objective of this study was to review the efficacy and safety of frovatriptan F versus rizatriptan R, zolmitriptan Z and almotriptan A, in women with menstrually related migraine IHS criteria through a pooled analysis of three individual studies. Subjects with a history of migraine with or without aura were randomized to F 2.5 mg or R 10 mg study 1, F or Z 2.5 mg study 2, and F or A 12.5 mg study 3. The studies had an identical multicenter, randomized, double-blind, crossover design. After treating three episodes of migraine in no more than 3 months with the first treatment, patients had to switch to the next treatment for other 3 months. 346 subjects formed intention-to-treat population of the main study; 280 of them were of a female gender, 256 had regular menses and 187 were included in the menstrual migraine subgroup analysis. Rate of pain free at 2, 4 and 24 h was 23, 52 and 67 % with F and 30, 61 and 66 % with comparators P = NS. Pain relief episodes at 2, 4 and 24 h were 37, 60 and 66 % for F and 43, 55 and 61 % for comparators P = NS. Rate of recurrence was significantly P < 0.05 lower under F either at 24 h 11 vs. 24 % comparators or at 48 h 15 vs. 26 % comparators. Number of menstrual migraine attacks associated with drug-related adverse events was equally low P = NS between F 5 % and comparators 4 %.

KeywordsAlmotriptan Menstrually related migraine Frovatriptan Rizatriptan Zolmitriptan The members of coordinators and investigators are listed in Appendix.

Download fulltext PDF



Autor: Gianni Allais - Vincenzo Tullo - Stefano Omboni - Chiara Benedetto - Grazia Sances - Dario Zava - Michel D. Ferrari - Genn

Fuente: https://link.springer.com/







Documentos relacionados