Altered small-world properties of gray matter networks in breast cancerReport as inadecuate

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BMC Neurology

, 12:28

First Online: 28 May 2012Received: 01 December 2011Accepted: 28 May 2012


BackgroundBreast cancer survivors, particularly those treated with chemotherapy, are at significantly increased risk for long-term cognitive and neurobiologic impairments. These deficits tend to involve skills that are subserved by distributed brain networks. Additionally, neuroimaging studies have shown a diffuse pattern of brain structure changes in chemotherapy-treated breast cancer survivors that might impact large-scale brain networks.

MethodsWe therefore applied graph theoretical analysis to compare the gray matter structural networks of female breast cancer survivors with a history of chemotherapy treatment and healthy age and education matched female controls.

ResultsResults revealed reduced clustering coefficient and small-world index in the brain network of the breast cancer patients across a range of network densities. In addition, the network of the breast cancer group had less highly interactive nodes and reduced degree-centrality in the frontotemporal regions compared to controls, which may help explain the common impairments of memory and executive functioning among these patients.

ConclusionsThese results suggest that breast cancer and chemotherapy may decrease regional connectivity as well as global network organization and integration, reducing efficiency of the network. To our knowledge, this is the first report of altered large-scale brain networks associated with breast cancer and chemotherapy.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-12-28 contains supplementary material, which is available to authorized users.

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Author: S M Hadi Hosseini - Della Koovakkattu - Shelli R Kesler


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