Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult ratsReportar como inadecuado




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Journal of Neural Transmission

, Volume 119, Issue 6, pp 679–684

First Online: 27 December 2011Received: 23 October 2011Accepted: 01 December 2011

Abstract

Targeting mechanisms that result in increased concentrations of kynurenic acid KYNA in the brain has been considered as a therapeutic approach for the treatment of epilepsy and certain neurodegenerative disorders. Recently, KYNA has been implicated in the effects produced by the high-fat and low-protein-carbohydrate ketogenic diet KD in a report demonstrating an increased production of KYNA in vitro by one of the ketone bodies, β-hydroxybutyrate, elevated by the KD. To further explore this association, brain concentrations of KYNA were compared in young 3 weeks old and adult 8–10 weeks old rats that were chronically exposed to the KD and regular diet. Exposure to the KD resulted in the anticipated elevations of β-hydroxybutyrate with accompanying decreases in glucose concentrations. In comparison to rats fed the regular diet, KYNA concentrations were significantly p < 0.05 increased in the hippocampus 256 and 363% increase in young and adult rats, respectively and in the striatum 381 and 191% increase in young and adult rats, respectively in KD-fed rats. KD-induced increases in KYNA concentrations in young versus adult rats in the hippocampus and striatum were comparable p > 0.05. Exposure to the KD had no effect on KYNA concentrations in the cortex of young and adult rats p > 0.05. In summary, chronic exposure to the KD resulted in several-fold increases in KYNA concentrations in discrete brain structures in the rats. Thus, the relevant clinical question for further exploration is whether KD-induced increases in KYNA concentrations can translate into clinically significant improvements in neuropsychiatric diseases associated with KYNA hypofunction.

KeywordsKetogenic diet Kynurenic acid Brain Epilepsy Neurodegenerative disorders Cortex Hippocampus Striatum AbbreviationsAMPA2-Amino-3-5-methyl-3-oxo-1,2-oxazol-4-ylpropanoic acid

KDKetogenic diet

KYNAKynurenic acid

NMDAN-Methyl-d-aspartate

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Autor: Tomasz Żarnowski - Tomasz Chorągiewicz - Maria Tulidowicz-Bielak - Sebastian Thaler - Robert Rejdak - Iwona Żarnowska - W

Fuente: https://link.springer.com/







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