Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumorsReport as inadecuate




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Sleep and Breathing

, Volume 16, Issue 2, pp 527–534

First Online: 27 May 2011Received: 17 December 2010Revised: 10 May 2011Accepted: 17 May 2011

Abstract

ObjectivesThe carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas HNP may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing.

DesignThis is a case–control study.

SettingThis study was conducted in a tertiary referral center.

Participants and main outcome measuresWe assessed fatigue, sleep, and exercise capacity in 74 HNP patients using three questionnaires Epworth Sleepiness Scale, St. George Respiratory Questionnaire, and a standard clinical sleep assessment questionnaire. Outcomes were compared to those of age- and sex-matched controls.

Results and conclusionsActivity, disturbance of psychosocial function, and total score were worse compared to controls 15.4 ± 18.5 vs. 7.2 ± 9.9, P = 0.007; 5.3 ± 10.5 vs. 1.2 ± 2.6, P = 0.008; and 10.4 ± 12.9 vs. 5.0 ± 4.8, P = 0.006, respectively. Patients reported more daytime fatigue, concentration difficulties, and depression 51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012. Waking up was reported to be less refreshing in HNP patients 53% vs. 73%, P = 0.038. Dysphonia was a predictor of symptoms, activity, disturbance of psychosocial function, and total scores. Remarkably, the presence of a carotid body tumor was an independent predictor of increased daytime sleepiness β = 0.287, P = 0.029. In conclusion, patients with HNP have remarkable sleep-related complaints. Especially the presence of carotid body tumors appears to be associated with increased daytime somnolence.

KeywordsParaganglioma Glomus tumors Carotid body tumor Sleep SDHD mutation AbbreviationsHNPHead-and-neck paraganglioma

CBTCarotid body tumor

ESSEpworth Sleepiness Scale

SGRQSt. George Respiratory Questionnaire

SCAQStandard clinical assessment questionnaire

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Author: Bas Havekes - Florine Kastelein - Agatha A. van der Klaauw - Nicolette van Duinen - Jeroen C. Jansen - Jan W. A. Smit

Source: https://link.springer.com/







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