Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and LatviaReport as inadecuate




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Gastroenterology Research and Practice - Volume 2015 2015, Article ID 204089, 10 pages -

Research Article

Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland

Department of Surgery, Collegium Medicum, Nicolaus Copernicus University, Ulica Jagiellonska 13-15, 85-067 Bydgoszcz, Poland

Asper Biotech, Vaksali 17a, 50410 Tartu, Estonia

The Estonian Academy of Sciences, Kohtu 6, 10130 Tallinn, Estonia

Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 23b-134, 51010 Tartu, Estonia

Estonian Genome Centre of University of Tartu, Riia 23, 23b-134, 51010 Tartu, Estonia

Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariškiu g. 2, LT-08661 Vilnius, Lithuania

State Research Institute, Innovative Medicine Center, Zygimantu 9, LT-01102 Vilnius, Lithuania

Vilnius Maternity Hospital, Santariškiu g. 2, LT-08661 Vilnius, Lithuania

Institute of Oncology, Vilnius University, 21-27 M. K. Ciurlionio, LT-03101 Vilnius, Lithuania

Hereditary Cancer Center, Stradins University, Dzirciema 16 Pardaugava, Riga LV-1007, Latvia

Pauls Stradins Clinical University Hospital, Pilsonu 13, Riga LV-1002, Latvia

Discipline of Medical Genetics, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, University Drive, Callaghan, NSW 2308, Australia

Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Locked Bag 1000, New Lambton, NSW 2305, Australia

Received 24 November 2014; Revised 31 March 2015; Accepted 15 April 2015

Academic Editor: Vicent Hernández

Copyright © 2015 Pablo Serrano-Fernandez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The continued identification of new low-penetrance genetic variants for colorectal cancer CRC raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668, already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia 166 cases and controls, Latvia 81 cases and controls, Lithuania 123 cases and controls, and Poland 795 cases and controls. Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample. Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.





Author: Pablo Serrano-Fernandez, Dagmara Dymerska, Grzegorz Kurzawski, Róża Derkacz, Tatiana Sobieszczańska, Zbigniew Banaszkiewic

Source: https://www.hindawi.com/



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