Relationship of Fungal Vaginitis Therapy to Prior Antibiotic ExposureReport as inadecuate

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Infectious Diseases in Obstetrics and Gynecology - Volume 11 2003, Issue 3, Pages 157-160

Professor of Obstetrics and Gynecology, West Virginia University Medical Center, Morgantown 26506-9186, WV, USA

Dean for University Research, Des Moines University-Osteopathic Medical Center, 3200 Grand Avenue, Des Moines, IA, USA

Received 30 April 2003; Accepted 7 July 2003

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: To address the putative association of antibiotic use and subsequent yeast vaginitis in a population ofnon-pregnant women.

Methods: Three hundred and sixteen women who received medical care in rural family medicine clinics enrolledin this study. Participants were pre-menopausal and non-pregnant and were followed until they used a course ofantifungal therapy for vaginitis, became pregnant or moved from the catchment area. At entry subjects were freeof vaginitis symptoms and had taken no antibiotics for 30 days.Patients were followed by repeated review of clinic records, hospital records and telephone or personal interviews.Data collection included documentation of episodes of antifungal treatment for vulvovaginal candidiasis andconfirmed antibiotic treatment or credible history of antibiotic use prior to the use of antifungal therapy.Physician-reported uses of antibiotic and antifungal as well as patient-reported uses of these were recorded.

Results: There were four reported cases of antifungal therapy following within a month of antibiotic use, incontrast to 484 antibiotic uses not followed by antifungal use. If time of observation was extended to 6 monthsfrom antibiotic use, there were 13 uses of antifungal therapy after antibiotics and 475 uses of antibiotics notfollowed by antifungal therapy.

Conclusion: Our results cast doubt on the association of antibiotics as a putative cause of yeast vulvovaginitis.

Author: Douglas D. Glover and Bryan Larsen



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