Neuroendocrine Tumor, Well Differentiated, of the Breast: A Relatively High-Grade Case in the Histological SubtypeReport as inadecuate

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Case Reports in PathologyVolume 2013 2013, Article ID 204065, 3 pages

Case Report

Division of Pathology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan

Division of Pathology and Laboratory Medicine, NTT Medical Center, Tokyo, Japan

Received 12 March 2013; Accepted 11 April 2013

Academic Editors: C.-C. Chiu, D. Tsuruta, and D. Vlachodimitropoulos

Copyright © 2013 Shogo Tajima and Hajime Horiuchi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary neuroendocrine carcinoma of the breast is a rare entity, comprising <1% of breast carcinomas. Described here is the case of a 78-year-old woman who developed an invasive tumor in the left breast measuring 2.0 cm x 1.5 cm x 1.2 cm. The tumor was composed of only endocrine elements in the invasive part. It infiltrated in a nested fashion with no tubular formation. Intraductal components were present both inside and outside of the invasive portion. Almost all carcinoma cells consisting of invasive and intraductal parts were positive for synaptophysin and neuron-specific enolase. According to the World Health Organization classification 2012, this tumor was subclassified as neuroendocrine tumor, well-differentiated. Among the subgroup, this tumor was relatively high-grade because it was grade 3 tumor with a few mitotic figures. Vascular and lymphatic permeation and lymph node metastases were noted. In the lymph nodes, the morphology of the tumor was similar to the primary site. No distant metastasis and no relapse was seen for one year after surgery. The prognosis of neuroendocrine carcinomas is thought to be worse than invasive mammary carcinomas, not otherwise specified. Therefore, immunohistochemistry for neuroendocrine markers is important in the routine practice to prevent overlooking neuroendocrine carcinomas.

Author: Shogo Tajima and Hajime Horiuchi



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