In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of BerberineReportar como inadecuado

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Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 2039897, 7 pages -

Research Article

Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafr El-Sheikh, Egypt

Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

Received 19 May 2016; Accepted 31 July 2016

Academic Editor: Mohammed S. Razzaque

Copyright © 2016 Mohammad Ahmad Mahmoud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet HFD intake for 6 weeks. Secondly, berberine was used as protective-curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance IR syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia with increased LDL-cholesterol and decreased HDL-cholesterol, and hypertriglyceridemia. Level of antioxidant enzymes in HFD group was higher than in normal one. Also there was an increasing in level of proinflammatory cytokines as interleukin- IL- 6 and IL-12 in HFD group. Feeding rats HFD for 6 weeks also decreased level of interferon gamma IFN-γ. The decreased level of IFN-γ has been shown to predict infection with infectious diseases especially viral infection. Treatment and protection with berberine 50 mg-kg-day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ.

Autor: Mohammad Ahmad Mahmoud, Doaa Ahmad Ghareeb, Heba Abdelghany Sahyoun, Ashraf Abdelhamed Elshehawy, and Mohammad Mohammad Elsaye



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