A hypothesis on chemical mechanism of the effect of hydrogenReportar como inadecuado

A hypothesis on chemical mechanism of the effect of hydrogen - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Medical Gas Research

, 2:17

First Online: 21 June 2012Received: 23 May 2012Accepted: 23 May 2012


Many studies have shown that hydrogen can play important roles on the antioxidant, anti-inflammatory and other protective effects. Ohsawa et al have proved that hydrogen can electively and directly scavenge hydroxyl radical. But this mechanism cannot explain more new experimental results. In this article, the hypothesis, which is inspired by H2 could bind to the metal as a ligand, come up to explain its extensive biology effect: Hydrogen could regulate particular metalloproteins by bonding M–H2 interaction it. And then it could affect the metabolization of ROS and signal transduction. Metalloproteins may be ones of the target molecules of H2 action. Metal ions may be appropriate role sites for H2 molecules. The hypothesis pointed out a new direction to clarify its mechanisms.

KeywordsHypothesis Hydrogen Mechanism Ligand Electronic supplementary materialThe online version of this article doi:10.1186-2045-9912-2-17 contains supplementary material, which is available to authorized users.

Penghui Shi, Wancang Sun contributed equally to this work.

Download fulltext PDF

Autor: Penghui Shi - Wancang Sun - Pengzhong Shi

Fuente: https://link.springer.com/

Documentos relacionados