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AIDS Research and TreatmentVolume 2012 2012, Article ID 169645, 11 pages

Research Article

Biobehavioral Unit, National Institute of Nursing Research, National Institutes of Health, DHHS, 10 Center Drive, Room 2-1339, Bethesda, MD 20892, USA

School of Education, University of Pittsburgh, 5918 Wesley W. Posvar Hall, 230 South Bouquet Street, Pittsburgh, PA 15261, USA

Department of Health and Community Systems, School of Nursing, University of Pittsburgh, 415 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, USA

Received 1 June 2012; Revised 6 September 2012; Accepted 7 September 2012

Academic Editor: Xia Jin

Copyright © 2012 Wendy A. Henderson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Persons living with human immunodeficiency virus HIV are living longer; therefore, they are more likely to suffer significant morbidity due to potentially treatable liver diseases. Clinical evidence suggests that the growing number of individuals living with HIV and liver disease may have a poorer health-related quality of life HRQOL than persons living with HIV who do not have comorbid liver disease. Thus, this study examined the multiple components of HRQOL by testing Wilson and Cleary’s model in a sample of 532 individuals 305 persons with HIV and 227 persons living with HIV and liver disease using structural equation modeling. The model components include biological-physiological factors HIV viral load, CD4 counts, symptom status Beck Depression Inventory II and the Medical Outcomes Study HIV Health Survey MOS-HIV mental function, functional status missed appointments and MOS-HIV physical function, general health perceptions perceived burden visual analogue scale and MOS-HIV health transition, and overall quality of life QOL Satisfaction with Life Scale and MOS-HIV overall QOL. The Wilson and Cleary model was found to be useful in linking clinical indicators to patient-related outcomes. The findings provide the foundation for development and future testing of targeted biobehavioral nursing interventions to improve HRQOL in persons living with HIV and liver disease.

Autor: Wendy A. Henderson, Angela C. Martino, Noriko Kitamura, Kevin H. Kim, and Judith A. Erlen



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