Caregiver burden in amyotrophic lateral sclerosis is more dependent on patients’ behavioral changes than physical disability: a comparative studyReportar como inadecuado




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BMC Neurology

, 12:156

First Online: 07 December 2012Received: 02 April 2012Accepted: 28 November 2012

Abstract

BackgroundBehavioral changes in patients with amyotrophic lateral sclerosis ALS mirror those found in frontotemporal dementia FTD. Considering the high rate of neuropsychiatric symptoms found in ALS patients, this paper examines whether caregiver burden is associated with behavioral changes over and above the physical disability of patients with ALS, and if the presence of caregivers’ depression, anxiety and stress also impacts on caregiver burden.

Methods140 caregivers of patients with ALS participated in a postal survey investigating patients’ neuropsychiatric symptoms Cambridge Behaviour Inventory Revised CBI-R, motor function Amyotrophic Lateral Sclerosis Functional Rating Scale Revised - ALSFRS-R, caregiver burden Zarit Burden Interview, and caregiver mood Depression, Anxiety and Stress Scale- DASS21. Seventy four percent of them were caregivers of patients with limb onset and 25.7% were caregivers of patients with bulbar onset.

ResultsModerate to severe behavioral changes were reported in 10-40% of patients with ALS. The levels of depression, anxiety and stress in the caregivers reached 20%. Burden was high in 48% of the caregivers. The strongest predictor of high caregiver burden was ALS patients’ abnormal behavior rather than physical disability, with an odds ratio of 1.4, followed by caregivers’ stress.

ConclusionsOur study has identified that behavioral changes e.g. disinhibition, impulsivity and caregiver stress have greater impact on caregiver burden than level and pattern of physical disability.

KeywordsALS Behavioral changes FTD Caregiver burden Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-12-156 contains supplementary material, which is available to authorized users.

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Autor: Patricia Lillo - Eneida Mioshi - John R Hodges

Fuente: https://link.springer.com/







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