Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of ageReportar como inadecuado

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Molecular Autism

, 3:17

First Online: 11 December 2012Received: 31 July 2012Accepted: 09 November 2012


BackgroundStudies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect. This study compares prenatal and postnatal sex steroid hormone levels in relation to autistic traits in 18 to 24-month-old children.

Fetal testosterone fT and fetal estradiol fE levels were measured in amniotic fluid from pregnant women n = 35 following routine second-trimester amniocentesis. Saliva samples were collected from these children when they reached three to four months of age and were analyzed for postnatal testosterone pT levels. Mothers were asked to complete the Quantitative Checklist for Autism in Toddlers Q-CHAT, a measure of autistic traits in children 18 to 24 months old.

FindingfT but not pT levels were positively associated with scores on the Q-CHAT. fE and pT levels showed no sex differences and no relationships with fT levels. fT levels were the only variable that predicted Q-CHAT scores.

ConclusionsThese preliminary findings are consistent with the hypothesis that prenatal but not postnatal androgen exposure, coinciding with the critical period for sexual differentiation of the brain, is associated with the development of autistic traits in 18 to 24 month old toddlers. However, it is recognized that further work with a larger sample population is needed before the effects of postnatal androgen exposure on autistic traits can be ruled out. These results are also in line with the fetal androgen theory of autism, which suggests that prenatal, organizational effects of androgen hormones influence the development of autistic traits in later life.

AbbreviationsASCAutism Spectrum Conditions

fEFetal estradiol

fTFetal testosterone

pTPostnatal testosterone

Q-CHATQuantitative Checklist for Autism in Toddlers.

Electronic supplementary materialThe online version of this article doi:10.1186-2040-2392-3-17 contains supplementary material, which is available to authorized users.

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Autor: Bonnie Auyeung - Jag Ahluwalia - Lynn Thomson - Kevin Taylor - Gerald Hackett - Kieran J O’Donnell - Simon Baron-Cohen


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