Analysis of Lung Metastases in Patients with Primary Extremity SarcomaReportar como inadecuado

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Sarcoma - Volume 7 2003, Issue 2, Pages 63-67

Department of Chest Diseases, Cancer Research Hospital, Ankara 06660, Turkey

Department of Orthopedics, Cancer Research Hospital, Ankara, Turkey

National Institute on Drug Abuse, Cellular Neurobiology Section, Baltimore, MD, USA

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose: To investigate the incidence, radiographic findings, and the time course for the appearence of lung metastases fromprimary extremity sarcoma.

Patients and methods: Four-hundred patients with extremity sarcoma were evaluated retrospectively for lung metastases.Multiple clinical factors were analyzed for possible influence on the metastases-free interval and subsequent metastasesdevelopment. Radiographic findings of metastases were also reviewed.

Results: Ninety of 400 patients 23% developed lung metastases. Median time from presentation to detection of metastasiswas 8.0 ± 1.1 months 95% CI: 6.02–9.98. More than 75% of patients developed metastases within 1 year after presentationof the primary sarcoma. As disease grade increased, the metastases-free intervals shortened significantly. Histologically,synoviosarcoma and osteogenic sarcoma were more often associated with the development of lung metastases. In thissubgroup, 54 patients 60%, the presence of solitary 11 or multiple 43 nodular metastases was the only radiologicalfinding. In 36 of 90 patients 40%, parenchymal mass, pleural effusion, hilar lymphadenopathy and pneumothorax werefound.

Conclusions: Twenty-three percent of patients in our study developed lung metastases. As the grade of the disease increased,metastases-free intervals are shortened. Although it has been reported that lung metastases in patients with extremitysarcomas may present as solitary or multiple nodules in earlier trials with radiographic screening methods, the current reviewof 400 patients found that a substantial number of patients may present radiological appearances other than nodularformations.

Autor: N. Songür, M. Dinç, C. Özdilekcan, S. Eke, U. Ok, and M. Oz



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