The Microanatomic Location of Metastatic Breast Cancer in Sentinel Lymph Nodes Predicts Nonsentinel Lymph Node InvolvementReportar como inadecuado




The Microanatomic Location of Metastatic Breast Cancer in Sentinel Lymph Nodes Predicts Nonsentinel Lymph Node Involvement - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Annals of Surgical Oncology

, Volume 15, Issue 5, pp 1309–1315

First Online: 06 February 2008Received: 14 October 2007Revised: 20 December 2007Accepted: 21 December 2007

Abstract

BackgroundThe majority of sentinel node SN positive breast cancer patients do not have additional non-SN involvement and may not benefit from axillary lymph node dissection ALND. Previous studies in melanoma have suggested that microanatomic localization of SN metastases may predict non-SN involvement. The present study was designed to assess whether these criteria might also be used to be more restrictive in selecting breast cancer patients who would benefit from an ALND.

MethodsA consecutive series of 357 patients with invasive breast cancer and a tumor-positive axillary SN, followed by an ALND, was reviewed. Microanatomic SN tumor features subcapsular, combined subcapsular and parenchymal, parenchymal, extensive localization, multifocality, and the penetrative depth from the SN capsule were evaluated for their predictive value for non-SN involvement.

ResultsNon-SN metastases were found in 136-357 cases 38%. Microanatomic location and penetrative depth of SN metastases were significant predictors for non-SN involvement <0.001; limited penetrative depth was associated with a low frequency of non-SN involvement with a minimal of 10%.

ConclusionsMicroanatomic location and penetrative depth of breast cancer SN metastases predict non-SN involvement. However, based on these features no subgroup of patients could be selected with less than 10% non-SN involvement.

KeywordsBreast cancer Sentinel node Axillary lymph node metastases Morphometry  Download fulltext PDF



Autor: Carolien H. M. van Deurzen - Cees A. Seldenrijk - Ron Koelemij - Richard van Hillegersberg - Monique G. G. Hobbelink -

Fuente: https://link.springer.com/article/10.1245/s10434-007-9803-z



DESCARGAR PDF




Documentos relacionados