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BMC Neurology

, 12:161

Demyelinating diseases

Abstract

BackgroundPhysical disability in multiple sclerosis MS is frequently characterized by impaired ambulation. Although walking tests have been successfully employed to assess walking ability in MS patients, data analytic procedures have predominantly relied on result-oriented parameters e.g. total distance covered during a given amount of time, whereas process-oriented, dynamic walking patterns have mostly been ignored. This is striking, since healthy individuals have been observed to display a stereotypical U-shaped pattern of walking speed during timed walking, characterized by relatively high speed during the initial phase, subsequent slowing and final acceleration. Objective of the current study was to test the utility of the 6 min Walk 6MW and the 12 min Walk 12MW for revealing putatively abnormal temporal dynamic features of walking in MS.

MethodsA group of 37 MS patients was divided into subgroups with regard to their level of disability analyzed with the Expanded Disability Status Scale EDSS; Mild MS Group, n = 20, EDSS 0 – 3.5; Moderate MS Group, n = 17, EDSS 4 – 5. Subsequently, both groups were compared to age-matched healthy controls n = 25 on both tests with regard to result-oriented characteristics mean walking speed, as well as dynamic features mean decline in walking speed, degree of observed U-shape.

ResultsBoth MS groups showed a significantly lower mean walking speed than healthy controls, independent of test duration. Compared to controls, the Moderate MS Group also slowed down more rapidly throughout both tests. The same pronounced decline in walking speed was observed for the Mild MS Group in case of the 12MW. Additionally, for both MS groups an attenuated U-shaped velocity pattern was observed relative to controls in the 6MW. Patients- subjective fatigue scores were more strongly correlated with the decline in walking speed than with the common parameter of mean walking speed in the 6MW.

ConclusionsMS patients display abnormal dynamics in their walking patterns. A pronounced linear decline in walking speed can be identified with the 12MW even in MS patients with seemingly mild disability. Similarly, the 6MW can be used to assess an abnormal walking profile. Particularly the linear decline in walking speed on this test shows a more robust association with subjective fatigue than mean walking speed. Dynamic walking parameters may hence represent valuable clinical features, serving as surrogate measures of motor fatigue. Future studies are needed to verify their prognostic value.

KeywordsMultiple sclerosis Ambulation Walking 6 minute walk 6MW 12 minute walk 12MW Linear trend U-shape Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-12-161 contains supplementary material, which is available to authorized users.

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Autor: Janina M Burschka - Philipp M Keune - Uwe Menge - Ulrich Hofstadt-van Oy - Patrick Oschmann - Olaf Hoos

Fuente: https://link.springer.com/







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