Signal alterations of the basal ganglia in the differential diagnosis of Parkinson’s disease: a retrospective case-controlled MRI data bank analysisReportar como inadecuado




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BMC Neurology

, 12:163

First Online: 29 December 2012Received: 10 April 2012Accepted: 26 December 2012

Abstract

BackgroundBased upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease PD, we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be useful as an additional technical tool in the diagnostic work-up.

MethodsRegion-of-interest analyses substantia nigra and globus pallidus internus of T2-weighted scans were performed in seventy subjects with PD, 170 age- and gender-matched controls and 38 patients with an atypical form of neurodegenerative Parkinsonian syndrome N = 11 multisystem atrophy, N = 22 progressive supranuclear palsy, N = 5 corticobasal syndrome.

ResultsIn patients with PD, significant changes in signal intensities within the substantia nigra were observed compared to controls at p < 0.001. For the globus pallidus internus, signal alterations in PD and progressive supranuclear palsy were found to be significant p < 0.001 if compared to controls. Furthermore, signal changes of substantia nigra correlated with signal intensities of globus pallidus internus in the ipsilateral hemisphere in both groups. Sensitivity was 86% and specificity was 90% for the combined analysis of substantia nigra and globus pallidus internus in the complete patient sample versus controls.

ConclusionsSignal alterations of substantia nigra and globus pallidus internus in routine magnetic resonance imaging were useful to distinguish patients with PD from controls. In addition, signal changes in globus pallidus internus could be used to differentiate progressive supranuclear palsy patients from controls. These analyses have the potential to serve as an additional non-invasive technical tool to support the individual differential diagnosis of PD.

KeywordsParkinson’s disease MRI Substantia nigra Globus pallidus internus Progressive supranuclear palsy Morphological changes Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-12-163 contains supplementary material, which is available to authorized users.

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Autor: Sarah Jesse - Jan Kassubek - Hans-Peter Müller - Albert C Ludolph - Alexander Unrath

Fuente: https://link.springer.com/







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