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Tuberculosis Research and Treatment - Volume 2014 2014, Article ID 202983, 8 pages -

Research Article

Centre for Development and Reproductive Health, Enugu, Enugu State 400001, Nigeria

National Tuberculosis and Leprosy Control Programme, Ministry of Health, Abakaliki, Ebonyi State 480001, Nigeria

Department of Internal Medicine, Federal Teaching Hospital, Abakaliki, Ebonyi State 480281, Nigeria

Received 7 August 2014; Revised 2 October 2014; Accepted 3 October 2014; Published 16 November 2014

Academic Editor: Brian Eley

Copyright © 2014 Daniel Chukwunweolu Oshi et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background.
Few studies have evaluated the rate of tuberculosis TB-human immunodeficiency virus HIV coinfection and the determinants of its treatment outcomes in Africa.
We aimed to determine the predictors of unsuccessful treatment outcomes in HIV-infected tuberculosis patients in Nigeria.
Methods.
A retrospective cohort study design was used to assess adult TB-HIV patients who registered for TB treatment in two health facilities in Ebonyi State, Southeast Nigeria, between January 2011 and December 2012.
Predictors of unsuccessful treatment outcomes were determined using multivariable logistic regression analysis.
Results.
Of 1668 TB patients, 342 20.5% were HIV coinfected.
Of these, 195 57% had smear-negative pulmonary TB and 11 3.2% had extrapulmonary TB.
Overall, 225 65.8% patients achieved successful outcomes, while 117 34.2% had unsuccessful outcomes.
The unsuccessful treatment outcomes were due to “default” 9.9%, “death” 19%, “treatment failure” 1.5%, and “transferring out” 3.8%.
Independent determinants for unsuccessful outcomes were receiving care at a public facility and noninitiation of antiretroviral therapy.
Conclusion.
There is need for the reevaluation of the quality of public sector treatment services provided for TB-HIV patients as well as further expansion of TB-HIV collaborative activities in rural areas, and interventions to reduce mortality and default rates among TB-HIV patients are urgently needed in Nigeria.





Autor: Daniel Chukwunweolu Oshi, Sarah Nakalema Oshi, Isaac Alobu, and Kingsley Nnanna Ukwaja

Fuente: https://www.hindawi.com/



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