Clinicopathological analysis of recurrence patterns and prognostic factors for survival after hepatectomy for colorectal liver metastasisReportar como inadecuado




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BMC Surgery

, 10:27

First Online: 27 September 2010Received: 20 May 2010Accepted: 27 September 2010

Abstract

BackgroundHepatectomy is recommended as the most effective therapy for liver metastasis from colorectal cancer CRCLM. It is crucial to elucidate the prognostic clinicopathological factors.

MethodsEighty-three patients undergoing initial hepatectomy for CRCLM were retrospectively analyzed with respect to characteristics of primary colorectal and metastatic hepatic tumors, operation details and prognosis.

ResultsThe overall 5-year survival rate after initial hepatectomy for CRCLM was 57.5%, and the median survival time was 25 months. Univariate analysis clarified that the significant prognostic factors for poor survival were depth of primary colorectal cancer ≥ serosal invasion, hepatic resection margin < 5 mm, presence of portal vein invasion of CRCLM, and the presence of intra- and extrahepatic recurrence. Multivariate analysis indicated the presence of intra- and extrahepatic recurrence as independent predictive factors for poor prognosis. Risk factors for intrahepatic recurrence were resection margin < 5 mm of CRCLM, while no risk factors for extrahepatic recurrence were noted. In the subgroup with synchronous CRCLM, the combination of surgery and adjuvant chemotherapy controlled intrahepatic recurrence and improved the prognosis significantly.

ConclusionsOptimal surgical strategies in conjunction with effective chemotherapeutic regimens need to be established in patients with risk factors for recurrence and poor outcomes as listed above.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2482-10-27 contains supplementary material, which is available to authorized users.

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Autor: Michihiro Hayashi - Yoshihiro Inoue - Koji Komeda - Tetsunosuke Shimizu - Mitsuhiro Asakuma - Fumitoshi Hirokawa - Yoshiharu

Fuente: https://link.springer.com/article/10.1186/1471-2482-10-27







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