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Molecular Pain

, 9:46

First Online: 08 September 2013Received: 23 February 2013Accepted: 30 August 2013


Multiple protein kinases affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in intracellular signal transduction pathways, and the consequences of this modulation may be spinal central sensitization. In contrast, the phosphatases catalyze an opposing reaction of de-phosphorylation, which may also modulate the functions of crucial proteins in signaling nociception. This is an important mechanism in the regulation of intracellular signal transduction pathways in nociceptive neurons. Accumulated evidence has shown that phosphatase 2A PP2A, a serine-threonine specific phosphatase, is implicated in synaptic plasticity of the central nervous system and central sensitization of nociception. Therefore, targeting protein phosphotase 2A may provide an effective and novel strategy for the treatment of clinical pain. This review will characterize the structure and functional regulation of neuronal PP2A and bring together recent advances on the modulation of PP2A in targeted downstream substrates and relevant multiple nociceptive signaling molecules.

Electronic supplementary materialThe online version of this article doi:10.1186-1744-8069-9-46 contains supplementary material, which is available to authorized users.

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Autor: Yun Wang - Yongzhong Lei - Li Fang - Yonggao Mu - Jing Wu - Xuan Zhang


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