Eating Behavior in Rats Subjected to Vagotomy, Sleeve Gastrectomy, and Duodenal SwitchReportar como inadecuado

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Journal of Gastrointestinal Surgery

, Volume 14, Issue 10, pp 1502–1510

First Online: 08 September 2010Received: 26 April 2010Accepted: 09 August 2010


Background-AimFood intake, eating behavior, and metabolic parameters in rats that underwent bilateral truncal vagotomy, sleeve gastrectomy, and duodenal switch procedures were examined.

MethodsRats were subjected to bilateral truncal vagotomy plus pyloroplasty VTPP, pyloroplasty PP, laparotomy, sleeve gastrectomy SG, or duodenal switch DS; with and without SG.

ResultsVTPP, but neither PP nor laparotomy, reduced body weight BW; 10% transiently 1 week postoperatively. SG reduced BW 10% for 6 weeks, while DS alone or SG followed by DS led to a continuous BW loss from 15% at 1 week to 50% at 8 weeks postoperatively. Food intake was higher and the satiety ratio was lower during the night than the day for all groups of surgeries. Neither VTPP nor SG had measurable effect on food intake, eating behavior and metabolic parameters. DS reduced daily food intake by more than 50%, which was associated with hypercholecystokininCCKemia, reduced meal size and increased satiety ratio, and increased fecal energy content measured at 8 weeks.

ConclusionsWeight loss after VTPP, SG, or DS differed in terms of degree, duration, and underlying mechanisms. DS without SG was most effective in the long-term, probably due to hyperCCKemia-induced reduction in food intake and long-limb intestinal bypass-induced malabsorption.

KeywordsBody weight Food intake Obesity surgery  Download fulltext PDF

Autor: Yosuke Kodama - Chun-Mei Zhao - Bård Kulseng - Duan Chen


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