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International Journal of Bipolar Disorders

, 1:16

First Online: 13 September 2013Received: 15 June 2013Accepted: 16 August 2013

Abstract

BackgroundPoor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder BD. We sought to identify modifiable factors that correlate with poor sleep quality in BD independent of residual mood symptoms.

MethodsA retrospective analysis was conducted to assess the association between the Pittsburgh Sleep Quality Index and clinical variables of interest in euthymic patients with DSM-IV BD n = 119 and healthy controls HC; n = 136 participating in the Prechter Longitudinal Study of Bipolar Disorder. Multivariable linear regression models were constructed to investigate the relationship between sleep quality and demographic and clinical variables in BD and HC participants. A unified model determined independent predictors of sleep quality.

Results and discussionEuthymic participants with BD and HC differed in all domains. The best fitting unified multivariable model of poor sleep quality in euthymic participants with BD included rapid cycling β = .20, p = .03, neuroticism β = .28, p = 2 × 10, and stressful life events β = .20, p = .02. Poor sleep quality often persists during euthymia and can be a target for treatment. Clinicians should remain vigilant for treating subjective sleep complaints independent of residual mood symptoms in those sensitive to poor sleep quality, including individuals with high neuroticism, rapid cycling, and recent stressful life events. Modifiable factors associated with sleep quality should be targeted directly with psychosocial or somatic treatment. Sleep quality may be a useful outcome measure in BD treatment studies.

KeywordsBipolar disorder Sleep Neuroticism Rapid cycling Stress Electronic supplementary materialThe online version of this article doi:10.1186-2194-7511-1-16 contains supplementary material, which is available to authorized users.

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Autor: Erika FH Saunders - Danielle M Novick - Julio Fernandez-Mendoza - Masoud Kamali - Kelly A Ryan - Scott A Langenecker - A

Fuente: https://link.springer.com/







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