Neuropathology of the posteroinferior occipitotemporal gyrus in children with autismReport as inadecuate

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Molecular Autism

, 5:17

First Online: 24 February 2014Received: 13 December 2013Accepted: 17 February 2014


BackgroundWhile most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is also important to identify whether areas that appear functionally normal are devoid of pathologic alterations. In this study we analyzed the posteroinferior occipitotemporal gyrus, an extrastriate area not considered to be affected in autism. This area borders the fusiform gyrus, which is known to exhibit functional and cellular abnormalities in autism.

FindingsNo studies have implicated posteroinferior occipitotemporal gyrus dysfunction in autism, leading us to hypothesize that neuropathology would not occur in this area. We indeed observed no significant differences in pyramidal neuron number or size in layers III, V, and VI in seven pairs of autism and controls.

ConclusionsThese findings are consistent with the hypothesis that neuropathology is unique to areas involved in stereotypies and social and emotional behaviors, and support the specificity of the localization of pathology in the fusiform gyrus.

KeywordsAutism Fusiform gyrus Neuropathology Posteroinferior occipitotemporal gyrus Stereology AbbreviationsFFAfusiform face area

FGfusiform gyrus

PIOTGposteroinferior occipitotemporal gyrus.

Electronic supplementary materialThe online version of this article doi:10.1186-2040-2392-5-17 contains supplementary material, which is available to authorized users.

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Author: Neha Uppal - Isabella Gianatiempo - Bridget Wicinski - James Schmeidler - Helmut Heinsen - Christoph Schmitz - Joseph D Bu


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