The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgeryReportar como inadecuado




The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Surgery

, 11:34

First Online: 15 December 2011Received: 25 June 2011Accepted: 15 December 2011

Abstract

BackgroundThe CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer.

Methods-DesignPatients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy 25 fractions of 2 Gy with concurrent capecitabine. Transanal Endoscopic Microsurgery TEM will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response.

Primary objective is to determine the number of patients with a near complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol.

DiscussionThe CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov NCT01273051

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2482-11-34 contains supplementary material, which is available to authorized users.

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Autor: Guus MJ Bökkerink - Eelco JR de Graaf - Cornelis JA Punt - Iris D Nagtegaal - Heidi Rütten - Joost JME Nuyttens - Est

Fuente: https://link.springer.com/article/10.1186/1471-2482-11-34







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