Prognostic analysis of combined curative resection of the stomach and liver lesions in 30 gastric cancer patients with synchronous liver metastasesReportar como inadecuado




Prognostic analysis of combined curative resection of the stomach and liver lesions in 30 gastric cancer patients with synchronous liver metastases - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Surgery

, 12:20

First Online: 12 October 2012Received: 10 June 2012Accepted: 09 October 2012

Abstract

BackgroundGastric cancer with synchronous liver metastasis remains a clinical treatment challenge. There has been a longstanding debate on the question whether surgical resection could be beneficial to long-term survival. This study is to investigate the effectiveness and prognostic factors of combined curative resection of the stomach and liver lesions in gastric cancer patients with synchronous liver metastases.

MethodsA total of 30 patients who underwent simultaneous curative gastric and liver resection from March 2003 to April 2008 were analyzed retrospectively. Univariate and multivariate analyses were performed to select independent factors for survival.

ResultsThe overall 1-, 2-, 3- and 5-year survival rates of 30 patients were 43.3%, 30.0%, 16.7% and 16.7%, respectively, with a median survival of 11.0 months and 5 patients still living by the time of last follow-up. Single liver metastasis p = 0.028 and an absence of peritoneal dissemination p = 0.007 were significantly independent prognostic factors for these gastric cancer patients with synchronous liver metastases. Major adverse events were protracted stomach paralysis in 2 patients and pulmonary infection in another 2 patients, all of whom recovered after conservative treatment.

ConclusionsThis descriptive study without control group found that patients with solitary liver metastasis and absence of peritoneal dissemination could have better survival benefit from simultaneous curative resection of the gastric cancer and liver metastases.

KeywordsGastric cancer Liver metastases Clinicopathological factors Prognosis Electronic supplementary materialThe online version of this article doi:10.1186-1471-2482-12-20 contains supplementary material, which is available to authorized users.

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Autor: Yan-Na Wang - Kun-Tang Shen - Jia-Qian Ling - Xiao-Dong Gao - Ying-Yong Hou - Xue-Fei Wang - Jing Qin - Yi-Hong Sun - Xin-

Fuente: https://link.springer.com/article/10.1186/1471-2482-12-20



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