Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat DietReportar como inadecuado




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Veterinary Medicine InternationalVolume 2010 2010, Article ID 262179, 8 pages

Research Article

Division of Gastroenterology, School of Medicine, Firat University, 23200 Elazig, Turkey

Department of Biochemistry, School of Medicine, Firat University, 23200 Elazig, Turkey

Department of Pathology, School of Medicine, Firat University, 23200 Elazig, Turkey

Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23200 Elazig, Turkey

Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA

Received 5 July 2010; Accepted 28 August 2010

Academic Editor: Jyoji Yamate

Copyright © 2010 Ibrahim Halil Bahcecioglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the preventive effect of lycopene on nonalcoholic steatohepatitis-induced by high-fat diet in rats. Forty male Sprague-Dawley rats were divided into 4 groups. They were fed standard diet, high-fat diet HFD, high-fat diet plus lycopene at a dose of 2 mg-kg body weight and the high-fat diet lycopene at a dose of 4 mg-kg BW for a period of 6 weeks. Inflammation, steatosis, 𝛼 -smooth muscle actin 𝛼 -SMA, and cytochrome P450 2E1 CYP 2E1 expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene. Significantly elevated levels of serum alanine aminotransferase ALT, aspartate aminotransferase AST, tumor necrosis factor TNF 𝛼 , and serum and liver malondialdehyde MDA were observed in rats fed the high-fat diet as compared to the control rats 𝑃 < . 0 1 . Supplementation with lycopene lowered serum MDA and tumor necrosis factor TNF- 𝛼 levels and elevated liver GSH level 𝑃 < . 0 0 1 . Insulin resistance was higher in the rats fed HFD than in rats supplemented with lycopene. The data indicate that supplementation with lycopene can reduce high-fat diet-induced oxidative stress to the cells.





Autor: Ibrahim Halil Bahcecioglu, Nalan Kuzu, Kerem Metin, Ibrahim Hanifi Ozercan, Bilal Ustündag, Kazim Sahin, and Omer Kucuk

Fuente: https://www.hindawi.com/



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