Sub-classification of Stage II colorectal cancer based on clinicopathological risk factors for recurrenceReportar como inadecuado

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Surgery Today

, Volume 44, Issue 5, pp 902–905

First Online: 21 December 2013Received: 02 February 2013Accepted: 17 April 2013


PurposeTo make a Stage II colorectal cancer CRC sub-classification based on clinicopathological factors.

MethodsThe subjects of this study were 422 patients with Stage II CRC, who underwent curative surgery with dissection of more than 12 lymph nodes. We used the logistic regression analysis or model and Cox’s proportional hazard regression model for analysis.

ResultsPreoperative carcinoembryonic antigen CEA level p = 0.0057, macroscopic type p = 0.0316, and depth of invasion p = 0.0401 were extracted as independent risk factors for recurrence, whereas the preoperative CEA level p = 0.0045 and depth of invasion p = 0.0395 were extracted as independent predictors of 5-year disease-free survival. We defined depth of invasion pT4 and the preoperative CEA level abnormal as risk factors for recurrence, and classified Grade A as a normal CEA level regardless of depth invasion, Grade B as depth of invasion to pT3 and an elevated CEA level, and Grade C as depth of invasion to pT4 and an elevated CEA level. There were significant differences in cumulative 5-year disease-free survival rates among each grade Grade A vs. Grade B, p = 0.0474; Grade A vs. Grade C, p < 0.0001; Grade B vs. Grade C, p = 0.0134.

ConclusionThe sub-classification of Stage II CRC, according not only to depth of invasion but also to preoperative CEA level, is important for predicting the prognosis.

KeywordsStage II colorectal cancer Clinicopathological factors Risk factors for recurrence Sub-classification An erratum to this article can be found at

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Autor: Takuzo Hashimoto - Michio Itabashi - Shinpei Ogawa - Tomoichiro Hirosawa - Yoshiko Bamba - Satoru Shimizu - Shingo Kameoka


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