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ISRN OncologyVolume 2012 2012, Article ID 167545, 6 pages

Research Article

Department of Orthopedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria

Division of Nuclear Medicine Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, Austria

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria

Received 6 March 2012; Accepted 12 April 2012

Academic Editors: N. A. Franken, G. Gatti, and J. Klijanienko

Copyright © 2012 Joerg Friesenbichler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Magnetic resonance imaging is considered as imaging modality of choice in diagnosis of desmoid tumors, though even this technique can lack the ability to distinguish aggressive fibromatosis from other benign or malignant soft tissue tumors. The aim of this study was to investigate if desmoid tumors would show an adequate tracer uptake in somatostatin receptor scintigraphy and moreover to correlate these results with immunohistochemical staining. Patients and Methods. Thirteen patients with desmoid tumors were examined with somatostatin receptor scintigraphy. Additionally, seven of these patients have been tested for the immunohistochemical expression of somatostatin receptor subtype 2A. The results of somatostatin receptor scintigraphy and the results of immunohistochemical staining somatostatin receptor subtype 2A were evaluated and correlated. Results. Somatostatin receptor scintigraphy revealed that eight of 13 affected patients 62% showed an enhanced tracer uptake. On the other hand, the correlation between the results of somatostatin receptor scintigraphy and immunohistochemical investigations was poor two out of seven cases. Conclusion. The current study demonstrated that desmoid tumors frequently express somatostatin receptor subtype 2, while immunohistochemical investigations did not correlate with these findings. This may likely be due to lack of standardization of this technique and also due to heterogeneous receptor distribution within the tumors.

Autor: Joerg Friesenbichler, Anja Molcan, Reingard Aigner, Patrick Sadoghi, Bernadette Liegl-Atzwanger, Werner Maurer-Ertl, Christi



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