Heat exposure and bicycling trigger recurrent aseptic meningitis: a case report

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BMC Neurology
, 14:230
Neurocritical care
Abstract
BackgroundAseptic meningitis associated with herpes simplex virus type 2 often has a relapsing-remitting clinical phenotype. Factors that lead to disease activation and reactivation are currently incompletely understood.
Case presentationWe describe the case of a 49-year-old Caucasian man who developed recurrent episodes of herpes simplex virus type 2-associated aseptic meningitis in the setting of heat exposure and bicycling. This case is compelling in that substantial data were available to the examining physicians on the amount of physical exercise and heat exposure. Strenuous physical activities or heat exposure in isolation did not cause re-occurrence of clinical signs and symptoms.
ConclusionsThis case illustrates that the dual activation of mechanical and temperature receptors in dorsal root ganglia may lead to the recurrent reactivation and afferent dissemination of latent herpes simplex virus type 2 in some patients.
AbbreviationsCSFCerebrospinal fluid
HSVHerpes simplex virus
MRIMagnetic resonance imaging
NKNatural killer
PCRPolymerase chain reaction
ThT helper cell
TLRToll-like receptor
WBCWhite blood cells
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Autor: Olaf Stuve - Ellen Marder - Annette Okai - Mark Stettner - Bernd C Kieseier
Fuente: https://link.springer.com/