Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label studyReportar como inadecuado




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The Journal of Headache and Pain

, 16:61

First Online: 30 June 2015Received: 01 May 2015Accepted: 12 June 2015

Abstract

BackgroundThe treatment of migraine headache is challenging given the lack of a standardized approach to care, unsatisfactory response rates, and medication overuse. Neuromodulation therapy has gained interest as an alternative to pharmacologic therapy for primary headache disorders. This study investigated the effects of non-invasive vagus nerve stimulation nVNS in patients with high-frequency episodic migraine HFEM and chronic migraine CM.

FindingsIn this open-label, single-arm, multicenter study, patients with HFEM or CM self-treated up to 3 consecutive mild or moderate migraine attacks that occurred during a 2-week period by delivering two 120-s doses of nVNS at 3-min intervals to the right cervical branch of the vagus nerve. Of the 50 migraineurs enrolled CM-HFEM: 36-14, 48 treated 131 attacks. The proportion of patients reporting pain relief, defined as a ≥50 % reduction in visual analog scale VAS score, was 56.3 % at 1 h and 64.6 % at 2 h. Of these patients, 35.4 % and 39.6 % achieved pain-free status VAS = 0 at 1 and 2 h, respectively. When all attacks N = 131 were considered, the pain-relief rate was 38.2 % at 1 h and 51.1 % at 2 h, whereas the pain-free rate was 17.6 % at 1 h and 22.9 % at 2 h. Treatment with nVNS was safe and well tolerated.

ConclusionNon-invasive vagus nerve stimulation may be effective as acute treatment for HFEM or CM and may help to reduce medication overuse and medication-associated adverse events.

KeywordsMigraine Neuromodulation Vagus nerve Acute treatment Patient preference Disability Piero Barbanti and Licia Grazzi contributed equally to this work.

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Autor: Piero Barbanti - Licia Grazzi - Gabriella Egeo - Anna Maria Padovan - Eric Liebler - Gennaro Bussone

Fuente: https://link.springer.com/







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