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Journal of Neural Transmission

, Volume 123, Issue 3, pp 297–316

First Online: 28 September 2015Received: 08 April 2015Accepted: 11 September 2015

Abstract

We analyzed the relation of several synchrony markers in the electroencephalogram EEG and Alzheimer’s disease AD severity as measured by Mini-Mental State Examination MMSE scores. The study sample consisted of 79 subjects diagnosed with probable AD. All subjects were participants in the PRODEM-Austria study. Following a homogeneous protocol, the EEG was recorded both in resting state and during a cognitive task. We employed quadratic least squares regression to describe the relation between MMSE and the EEG markers. Factor analysis was used for estimating a potentially lower number of unobserved synchrony factors. These common factors were then related to MMSE scores as well. Most markers displayed an initial increase of EEG synchrony with MMSE scores from 26 to 21 or 20, and a decrease below. This effect was most prominent during the cognitive task and may be owed to cerebral compensatory mechanisms. Factor analysis provided interesting insights in the synchrony structures and the first common factors were related to MMSE scores with coefficients of determination up to 0.433. We conclude that several of the proposed EEG markers are related to AD severity for the overall sample with a wide dispersion for individual subjects. Part of these fluctuations may be owed to fluctuations and day-to-day variability associated with MMSE measurements. Our study provides a systematic analysis of EEG synchrony based on a large and homogeneous sample. The results indicate that the individual markers capture different aspects of EEG synchrony and may reflect cerebral compensatory mechanisms in the early stages of AD.

KeywordsEEG synchrony markers Alzheimer’s disease Compensatory mechanism Coherence Granger causality Canonical correlation The study has been supported by Project no. 827462 funded by a grant from the Austrian Research Promotion Agency FFG.

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Autor: Markus Waser - Heinrich Garn - Reinhold Schmidt - Thomas Benke - Peter Dal-Bianco - Gerhard Ransmayr - Helena Schmidt - Ste

Fuente: https://link.springer.com/



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