The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosisReportar como inadecuado




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Neurological Sciences

, Volume 37, Issue 3, pp 417–421

First Online: 21 November 2015Received: 28 July 2015Accepted: 03 November 2015

Abstract

Diagnosis of amyotrophic lateral sclerosis ALS is based on clinical criteria and electrophysiological tests electromyography, and transcranial magnetic stimulation. In the search for ALS biomarkers, the role of imaging procedures is currently emphasized, especially modern MR techniques. MR procedures were performed on 15 ALS patients and a sex- and age-matched control group. The MR examinations were performed with a 1.5-T MR unit, and the protocol consisted of sagittal T1-weighed images, sagittal and axial T2-weighed images, and sagittal T2-weighed FAT SAT images followed by an axial diffusion tensor imaging DTI sequence of the cervical spinal cord. FA values in individual segments of the cervical spinal cord were decreased in the ALS group in comparison with the control group. After comparing FA values for anterior, posterior, and lateral corticospinal columns, the greatest difference was observed between the C2 and C5 segments. Spinal cord assessment with the use of FA measurements allows for confirmation of the motor pathways lesion in ALS patients. The method, together with clinical criteria, could be helpful in ALS diagnosis, assessment of clinical course, or even the effects of new drugs. The results also confirmed the theory of the generalized character of ALS.

KeywordsAmyotrophic lateral sclerosis Motor pathway Cervical spinal cord Neuroimaging Fractional anisotropy Diffusion tensor imaging  Download fulltext PDF



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Fuente: https://link.springer.com/







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