Association of serum myokines and aerobic exercise training in patients with spinal cord injury: an observational studyReportar como inadecuado

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BMC Neurology

, 16:142

Movement disorders


BackgroundPatients with spinal cord injury SCI have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literature regarding the effect of aerobic training on patients with SCI is scarce. This study evaluated changes in parameters of exercise physiology and serum myokines immediately after exercise and after a training program among patients with SCI.

MethodsMale patients with SCI and age- and sex-matched healthy individuals were recruited. Cardio-pulmonary exercise testing CPET was used to determine oxygen uptake at peak exercise and anaerobic threshold in both groups. The patients with SCI attended aerobic exercise training for 36 sessions within 12–16 weeks. Basic data, hemodynamic and exercise physiology parameters, and serum myokine myostatin, IGF-1, and follistatin concentrations were measured pre- and post-exercise in both groups, and were repeated in patients with SCI post-training.

ResultsEleven patients with SCI underwent CPET and 5 completed the training. The 11 patients and 16 healthy adults had no differences in baseline serum myokine concentrations before CPET. Immediately after the CPET, the reference group had an 18 ± 19 % increase in serum IGF-1, while the patients had no observable myokine changes. After aerobic exercise training, the 5 patients had a 48 ± 18 % increase in serum myostatin compared to the pre-training level, although the body weight and exercise physiology parameters remained unchanged.

ConclusionsAcute exercise to exhaustion in CPET results in an immediate increase in serum IGF-1 in healthy individuals while aerobic exercise training results in increased serum myostatin in patients with SCI.

KeywordsSpinal cord injury Aerobic capacity Cardio-pulmonary exercise testing Myostatin Insulin-like growth factor-1  Download fulltext PDF

Autor: Der-Sheng Han - Ming-Yen Hsiao - Tyng-Guey Wang - Ssu-Yuan Chen - Wei-Shiung Yang


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