Prognostic value of preoperative inflammatory response biomarkers in patients with esophageal cancer who undergo a curative thoracoscopic esophagectomyReportar como inadecuado




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BMC Surgery

, 16:66

Visceral and general surgery

Abstract

BackgroundSeveral inflammatory response biomarkers, including lymphocyte-to-monocyte ratio LMR, neutrophil-to-lymphocyte ratio NLR, and platelet-to-lymphocyte ratio PLR have been reported to predict survival in various cancers. The aim of this study is to evaluate the clinical value of these biomarkers in patients undergoing curative resection for esophageal cancer.

MethodsThe LMR, NLR and PLR were calculated in 147 consecutive patients who underwent esophagectomy between January 2006 and February 2015. We examined the prognostic significance of the LMR, NLR, and PLR in both elderly and non-elderly patients. We evaluated the cancer-specific survival CSS, with the cause of death determined from the case notes or computerized records.

ResultsUnivariate analyses demonstrated that TNM pStage p < 0.0001, tumor size p = 0.0014, operation time p = 0.0209, low LMR p = 0.0008, and high PLR p = 0.0232 were significant risk factors for poor prognosis. Meanwhile, TNM pStage p < 0.0001 and low LMR p = 0.0129 were found to be independently associated with poor prognosis via multivariate analysis.

In non-elderly patients, univariate analyses demonstrated that TNM pStage p < 0.0001, tumor size p = 0.0001, operation time p = 0.0374, LMR p < 0.0001, and PLR p = 0.0189 were significantly associated with a poorer prognosis. Multivariate analysis demonstrated that TNM pStage p = 0.001 and LMR p = 0.0007 were independent risk factors for a poorer prognosis.

In elderly patients, univariate analysis demonstrated that that TNM pStage p = 0.0023 was the only significant risk factor for a poor prognosis.

ConclusionsLMR was associated with cancer-specific survival CSS of esophageal cancer patients after curative esophagectomy. In particular, a low LMR was a significant and independent predictor of poor survival in non-elderly patients. The LMR was convenient, cost effective, and readily available, and could thus act as markers of survival in esophageal cancer.

KeywordsEsophageal cancer Lymphocyte to monocyte ratio LMR Neutrophil to lymphocyte ratio NLR Platelet lymphocyte ratio PLR Prognostic predictor AbbreviationsAUCArea under curve

CBCComplete blood cell

CSSCancer-specific survival

LMRLymphocyte to monocyte ratio

NLRNeutrophil to lymphocyte ratio

PLRPlatelet lymphocyte ratio

ROCReceiver operating curve

SCCSquamous cell carcinoma

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Autor: Noriyuki Hirahara - Takeshi Matsubara - Yoko Mizota - Shuichi Ishibashi - Yoshitsugu Tajima

Fuente: https://link.springer.com/article/10.1186/s12893-016-0179-5







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