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Chinese Neurosurgical Journal

, 3:4

First Online: 16 January 2017Received: 14 July 2016Accepted: 08 December 2016

Abstract

Here, we compiled ten papers detailing recent strides in the field of stem cell therapy, which address critical issues relevant to pursuing this experimental treatment for clinical applications in brain disorders. Topics include efficacy, safety, and mechanism of action underlying cell therapy, emerging technologies and combination pharmacotherapies with cell transplantation directed at improving the functional outcomes, and evaluation of key translational components of advancing novel therapeutics to the clinic, including the need for vis-à-vis comparisons with the gold standard of treatment post-injury i.e., physical rehabilitation. A bioethics paper is also incorporated here to further appreciate the current status of cell therapy in the community setting. The overall goal of this special volume is to provoke a meaningful assessment of the lessons we have learned in recent years and to use such knowledge to carefully translate safe and effective applications of cell therapy, and its mechanism of action for the treatment of neurological disorders.

KeywordsBrain disorders Cell transplantation Safety Efficacy Mechanism Clinical trials Bioethics Biomaterials AbbreviationsAFSCamniotic fluid stem cells

AMSCamniotic membrane stem cells

ASNTRAmerican Society for Neural Therapy and Repair

BDNFbrain-derived neurotrophic factors

BMbone marrow

BMDSCsbone marrow-derived stem cells

BMP7bone morphogenetic protein 7

BNPbrain natriuretic peptide

CARTcocaine and amphetamine-regulated transcript

EPCendothelial progenitor cells

ESembryonic stem cells

MAPCsmultipotent adult progenitor cells

MCAOmiddle cerebral artery occlusion

MICU1mitochondrial calcium uptake 1

MSCmesenchymal stem cells

NIHNational Institutes of Health

NPCneuroprogenitor cells

NT2Nneuroteratocarcinoma-derived neural progentior cells

NT-proBNPN-terminal-pro-brain natriuretic peptide

PFTɑPifithrin-α

PLGApolyDL-lactic-co-glycolic acid

PRNCsprimary rat neuronal cells

RCMsrat cardiac myocytes

SVZsubventricular zone

tPAtissue plasminogen activator

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Autor: Sydney Corey - Shaila Ghanekar - Jake Sokol - John H. Zhang - Cesar V. Borlongan

Fuente: https://link.springer.com/







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